Scientist - In Vitro Global Safety Pharmacology

Job title: Scientist - In Vitro Global Safety Pharmacology

Location – Groton CT

Duration: 12+ Months

Role Description:

This position will be responsible for supporting drug discovery by performing in vitro experiments to assess the off-target pharmacology of novel compounds using both cellular and biochemical assays.

Responsibilities:

Work independently and as part of a team to help design, execute, analyze / interpret data generated from experiments from biochemical and in vitro cell-based assays.

Specific duties to include:

● Apply scientific knowledge in running early in-vitro safety screening assays (384 well plate based; medium throughput) using a range of in vitro cell based, enzyme assays and transporter assays.

● Support screening efforts by performing aseptic cell culture work for multiple cell lines.

● Keep detailed experimental records and prepare study summaries and technical reports.

● Have a working knowledge of analysis tools such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentations.

● Contribute to building an innovative culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and in vitro expertise.

Basic Qualifications:

● Bachelor's degree plus 5 years pertinent laboratory experience in Pharmacology (or related field).

● Previous experience running cell/enzyme-based assay platforms in a medium to high throughput environment is required. Experience using plate-based instrumentation (liquid handling, fluorescent plate readers, plate-based scintillation counters)

● Cell culture experience

● Eagerness to learn new laboratory techniques

● Ability to work in fast paced environment and meet deadlines.

● Strong organizational, interpersonal and communication skills as well as ability to perform tasks with minimal supervision. Team player attitude is a must.

● Excellent time-management skills and ability to follow pre-established experimental designs and troubleshoot problems in an independent manner.

Preferred Qualifications:

● Working knowledge of receptor pharmacology principles

● Experience with Molecular Devices FLIPR, Revvity Envision and Envision Nexus, Perkin Elmer Microbeta2 platforms

● Experience using Revity Signals Electronic Notebook