Principal Clinical Scientist

About The Role

What if your deep expertise in clinical trial design and regulatory science could directly influence how AI understands and evaluates real-world medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research — helping ensure that the clinical intelligence built into next-generation AI systems meets the standards expected in real regulatory submissions.

This is a fully remote, flexible contract role designed for experienced clinical scientists who want to do meaningful work at the intersection of medicine and AI — on their own schedule.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory expectations
• Evaluate AI-generated clinical analyses for scientific soundness and methodological rigor
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Work independently and asynchronously — fully on your own schedule

• Senior-level experience designing clinical trial protocols intended for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent international bodies
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Naturally detail-oriented with a systematic, evidence-driven approach to evaluation
• Clear and precise written communicator — able to articulate complex scientific reasoning in structured feedback

• Prior experience with data annotation, data quality assurance, or evaluation systems
• Familiarity with AI tools or clinical informatics platforms
• Background in pharmacology, oncology, rare disease, or another specialist therapeutic area
• Experience contributing to regulatory dossiers, CTD submissions, or scientific advisory processes

• Work directly on frontier AI systems impacting clinical and biomedical research at a global scale
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, task-based expert work
• Influence how AI understands, evaluates, and reasons about real-world clinical evidence
• Collaborate with world-leading AI research teams and labs
• Potential for ongoing work and contract extension as new projects launch