Executive Director, Global Manufacturing Lead

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Position Summary

Owns global manufacturing strategy, capacity outlook, and performance management across external CMOs. Establishes network governance routines (KPIs, performance reviews, escalation paths) to drive predictable execution aligned to demand, inventory strategy, and launch timelines. Partners with Quality to support compliant execution and sustained inspection readiness and coordinates resolution of supply-impacting quality events. Aligns with CMC / MSAT on tech transfers, process changes, and validation readiness so technical deliverables support on-time supply. Sponsors continuous improvement across reliability, yield, cycle time, and cost.

Key Responsibilities

Network Strategy, Capacity & Performance

• Own network capacity outlook and performance cadence across sites / CMOs, drive corrective actions for gaps
• Align manufacturing priorities to supply plans, inventory targets, and launch / cutover commitments
• Produce deliverables such as network capacity reviews, performance scorecards, and recovery plans

Compliance & Technical Readiness

• Partner with Quality to maintain compliant execution and inspection readiness, coordinate responses to supply-impacting quality events
• Coordinate with CMC / MSAT on transfers, changes, and validation dependencies, escalate risks to milestones
• Produce deliverables such as readiness trackers and cross-functional risk / decision packs

Continuous Improvement & Best Practice Scaling

• Sponsor CI initiatives (yield, cycle time, reliability, cost) and scale effective practices across the network
• Ensure consistent KPI definitions and reporting to enable comparable performance management
• Produce deliverables such as CI charters, KPI definitions, and best-practice playbooks

Required Qualifications

• BS+ (Engineering, Physical Science, Supply Chain, or related)
• 18+ years manufacturing / network leadership with site / CMO governance experience
• Demonstrated experience managing capacity constraints and performance recovery in complex networks

Preferred Qualifications

• Experience in pharmaceutical / biotech GMP manufacturing and external manufacturing models (preferred)
• Experience leading launch readiness governance and multi-site / CMO tech transfer coordination

Key Competencies

• Manufacturing network governance, capacity strategy, and performance management, KPI cadence and corrective action leadership
• Partner governance and performance management across CMOs, escalation paths, accountability, and on-time recovery
• Cross-functional leadership, escalation, and executive-ready risk / decision communication
• GMP-aware operational decision-making and inspection readiness alignment with Quality and site partners
• Continuous improvement (yield, reliability, cycle time) and scaling best practices across a network

We are committed to fostering an inclusive and diverse workplace and do not discriminate on the basis of any legally protected characteristics. Madrigal processes your personal data in connection with its recruitment and talent sourcing activities in accordance with applicable data protection laws. Further information about how your personal data is processed, together with details of your rights and how to exercise them, is available in our Job Applicant Privacy Notice, which is made available to you if you apply through Workday.

Please note that this job description is not exhaustive and may evolve over time. Only shortlisted candidates will be contacted. Applicants must be authorized to work in the country of employment at the time of application. Employment terms, where applicable, will be governed by relevant collective bargaining agreements.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.