Principal Software Engineer, Full Stack

Join us in shaping the future of science! We are seeking a Principal Software Engineer with full stack experience to join our software platform team, where you’ll collaborate with software engineers, lab scientists, and machine learning engineers to build cutting-edge tools for automated scientific analysis and more. This role spans web services and data engineering, with a strong emphasis on Python development for scientific applications. If you thrive in a collaborative, fast-paced environment and bring best practices in git, development workflows, and user-centered design, we want to hear from you!

What You'll Be Building

• Design & Build Services and Front-ends: Design and build high-performance, secure, and well-documented code that integrate with an ecosystem of existing services and apps.
• Performance & Reliability: Diagnose and optimize system bottlenecks, ensuring high availability and low-latency performance across large-scale workloads.
• Cloud & Infrastructure: Leverage AWS services, Kubernetes and modern DevOps practices to build and deploy production-grade systems at scale.
• Cross-Functional Collaboration: Work with ML researchers, engineers, and scientists to integrate data pipelines, APIs, and cloud infrastructure into scientific workflows and services.

• Bachelor’s or Master’s degree in Computer Science, Engineering, or related field.
• 4-8 years of experience writing software in a commercial setting.
• Full Stack Development: Experience developing web apps across the full stack (React, TypeScript, Monorepos like Nx, TailWind, FastAPI, SQL/NoSQL, Python, Pydantic)
• Cloud & DevOps Knowledge: Hands-on experience with AWS, GCP, or Azure; strong understanding of Kubernetes and containerization, infrastructure-as-code (Terraform, CloudFormation), and CI/CD pipelines (GitHub Actions).
• Communication & Collaboration: Acute listening skills, and a proven track record of working cross-functionally with scientists, data engineers, and product teams; able to explain complex ideas to diverse audiences.
• Problem Solving: Proven ability to take ownership of complex backend challenges, balancing trade-offs between scalability, performance, and maintainability.

• Hands-On with Latest AI Tools: Exposure to AI technologies such as Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), or agentic frameworks, as well as experience leveraging AI to improve development performance.
• Experience with ORMs: Experience with and web services for CRUD services (SQLModel, FastAPI, Django).
• Orchestration Systems: Experience with orchestrators tools (Airflow, Prefect, Temporal, Dagster).
• Familiarity with Python for Science: Familiarity with data science and ML libraries (pandas, numpy, scipy, jax, pytorch).
• Domain Background: Exposure to laboratory software or analytics for life sciences, material sciences, or related fields.
• Experience with laboratory devices, robotics, or hardware drivers.

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science.  We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method.  We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before. Learn more about this mission at  www.lila.ai

If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, we encourage you to apply.

We’re All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

CompensationWe offer competitive compensation including bonus potential and generous early equity. The final offer will reflect your unique background, expertise, and impact.

Expected Base Salary Range: $204,000 USD - $272,000 USD