Research Associate (Chemistry)

About Us:

Arnatar Therapeutics is a clinical stage biotechnology company solving critical problems in human health through the discovery and development of innovative medicines. We specialize in targeting RNA for cures across many diseases through a precise RNA medical approach. We are advancing cutting edge antisense technologies to modulate gene expression in a desired way and to discover and develop next generation medicines for large and rare diseases. Our team is comprised of industry leading experts in siRNA and ASO technology who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of RNA targeting drugs that enables rational design and rapid development of antisense medicines to patients with unmet medical needs, while prosecuting a robust pipeline of programs through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.

Research Associate Chemistry/Oligonucleotides:

Arnatar is seeking a Research Associate Oligonucleotides. This Research level R&D position requires strategic thinking, an ability to work pro-actively and collaboratively, portfolio mindset and deep scientific expertise across several of the following disciplines: Applicants should have strong experience in oligonucleotide drug synthesis and optimization with a proven track record in delivering clinical candidates. Working as part of a cross-functional team spanning chemistry, biology, analytical sciences, pharmacology, DMPK, and toxicology, the candidate will also manage collaborations and CRO resources as needed. This candidate must have a “can do” attitude with a hands-on approach, being in the lab with direct reports and staff. This role is a Chemistry lab role with emphasis on the oligo production in the lab and short timelines.

Role and responsibilities:

• Design, synthesis, purification, and analysis of chemically modified oligonucleotides
• Improve upon and/or develop new synthetic methods and processes to expand the current capabilities
• Utilize analytical instrumentation such as UV-Vis spectroscopy, HPLC, and LC-MS for the analysis of both crude and purified synthetic products
• Effectively troubleshoot synthetic/process issues and independently find solutions
• Improve upon and/or develop new methods and automation for the downstream processing of synthetic oligonucleotides and their subsequent analysis/purification and annealing into siRNA duplexes
• Analyze, interpret, and organize analytical data to present to team members

Required qualifications:

• Bachelor’s or Master’s degree in Chemistry, or a related field
• 0-4 years of work experience, preferably in an industrial setting
• Experience in solid-phase synthesis of biomolecules and a good understanding of the procedures involved in SPS are preferred
• Experience with instrumentation such as HPLC, LC-MS, UV-Vis spectrometry, etc. is required. Experience in developing new chromatographic methods (IEX/RP HPLC, SPE, LC-MS) is a plus
• Ability to function within a highly interdisciplinary environment is a must
• Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required
• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment

Experience in the following areas:

• Solid experience in oligonucleotide synthesis is required
• Bioconjugation chemistry is preferred
• Cell delivery technologies is a plus
• Understanding of the IP and regulatory landscape around oligonucleotide therapeutics
• Experience in building robust data packages to support IND filings
• High level of creativity and productivity with strong problem-solving skills, synthetic methods, and reaction mechanisms and analytical methodology
• Extensive experience in program leadership with a demonstrated track record of driving data-based scientific decision-making
• Exceptional interpersonal skills, ability to build and maintain relationships with colleagues at all levels of the organization
• Demonstrated ability to advance drug discovery programs from biological targets to delivery of development compounds

Preferred Qualifications:

• Desire to work with the team in the lab making novel oligos and developing new processes
• Experience interacting with CMOs for GLP tox batch and GMP synthesis

What we offer:

• Health Benefits
• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Weekly town halls to share business and scientific updates

Arnatar Therapeutics is headquartered in San Diego, California.

Arnatar is an EEOC Employer.

Recruiters: Please do not contact.

Job Type: Full-time

Pay: $70,000.00 - $80,000.00 per year

Schedule:

• 8 hour shift

Work Location: In person